ADDITIONAL NOTES. VII.

OLD AGE AND DEATH.

I. Effects of Age.

         THE immediate cause of the infirmities of age, or of the progress of life to death, has not yet been well ascertained. The answer to the question, why animals become feeble and diseased after a time, though nourished with the same food which increased their growth from infancy, and afterwards supported them for many years in unimpaired health and strength, must be sought for from the laws of animal excitability, which, though at first increased, is afterwards diminished by frequent repetitions of its adapted stimulus, and at length ceases to obey it.
         1. There are four kinds of stimulus which induce the fibres to contract, which constitute the muscles or the organs of sense; as, first, The application of external bodies, which excites into action the sensorial power of irritation; 2dly, Pleasure and pain, which excite into action the sensorial power of sensation; 3dly, Desire and aversion, which excite into action the power of volition; and lastly, The fibrous contractions, which precede association, which is another sensorial power; see Zoonomia, Vol. I. Sect. II. 13.
         Many of the motions of the organic system, which are necessary to life, are excited by more than one of these stimuli at the same time, and some of them occasionally by them all. Thus respiration is generally caused by the stimulus of blood in the lungs, or by the sensation of the want of oxygen; but is also occasionally voluntary. The actions of the heart also, though generally owing to the stimulus of the blood, are also inflamed by the association of its motions with those of the stomach, whence sometimes arises an inequality of the pulse, and with other parts of the system, as with the capillaries, whence heat of the skin in fevers with a feeble pulse, see Zoonomia. They are also occasionally influenced by sensation, as is seen in the paleness occasioned by fear, or the blush of shame and anger; and lastly the motions of the heart are sometimes assisted by volition; thus in those who are much weakened by fevers, the pulse is liable to stop during their sleep, and to induce great distress; which is owing at that time to the total suspension of voluntary power; the same occurs during sleep in some asthmatic patients.
         2. The debility of approaching age appears to be induced by the inactivity of many parts of the system, or their disobedience to their usual kinds and quantities of stimulus: thus the pallid appearance of the skin of old age is owing to the inactivity of the heart, which ceases to obey the irritation caused by the stimulus of the blood, or its association with other moving organs with its former energy; whence the capillary arteries are not sufficiently distended in their diastole, and consequently contract by their elasticity, so as to close the canal, and their sides gradually coalesce. Of these, those which are most distant from. the heart, and of the smallest diameters, will soonest close, and become impervious; hence the hard pulse of aged patients is occasioned by the coalescence of the sides of the vasa vasorum, or capillary arteries of the coats of the other arteries.
         The veins of elderly people become turgid or distended with blood, and stand prominent on the skin; for as these do not possess the elasticity of the arteries, they become distended with accumulation of blood; when the heart by its lessened excitability does not contract sufficiently forcibly, or frequently, to receive, as fast as usual, the returning blood; and their apparent prominence on the skin is occasioned by the deficient secretion of fat or mucus in the cellular membrane; and also to the contraction and coalescence and consequent less hulk, of many capillary arteries.
         3. Not only the muscular fibres lose their degree of excitability from age, as in the above examples; and as may be observed in the tremulous hands and feeble step of elderly persons; but the organs of sense become less excitable by the stimulus of external objects; whence the sight and hearing become defective; the stimulus of the sensorial power of sensation also less affects the aged, who grieve less for the loss of friends or for other disappointments; it should nevertheless be observed, that when the sensorial power of irritation is much exhausted, or its production much diminished; the sensorial power ofsensation appears for a time to be increased; as in intoxication there exists a kind of delirium and quick flow of ideas, and yet the person becomes so weak as to totter as he walks; but this delirium is owing to the defect of voluntary power to correct the streams of ideas by intuitive analogy, as in dreams: see Zoonomia: and thus also those who are enfeebled by habits of much vinous potation, or even by age alone, are liable to weep at shaking hands with a friend, whom they have not lately seen; which is owing to defect of voluntary power to correct their trains of ideas caused by sensation, and not to the increased quantity of sensation, as I formerly supposed.
         The same want of voluntary power to keep the trains of sensitive ideas consistent, and to compare them by intuitive analogy with the order of nature, is the occasion of the starting at the clapping to of a door, or the fall of a key, which occasions violent surprise with fear and sometimes convulsions, in very feeble hysterical patients, and is not owing I believe (as I formerly supposed) to increased sensation; as they are less sensible to small stimuli than when in health.
         Old people are less able also to perform the voluntary exertions of exercise or of reasoning, and lastly the association of their ideas becomes more imperfect, as they are forgetful of the names of persons and places; the associations of which are less permanent, than those of the other words of a language, which are more frequently repeated.
         4. This disobedience of the fibres of age to their usual stimuli, has generally been ascribed to repetition or habit, as those who live near a large clock, or a mill, or a waterfall, soon cease to attend to the perpetual noise of it in the day, and sleep during the night undisturbed. Thus all medicines, if repeated too frequently, gradually lose their effect; as wine and opium cease to intoxicate: some disagreeable tastes, as tobacco, by frequent repetition cease to be disagreeable; grief and pain gradually diminish, and at length cease altogether; and hence, life itself becomes tolerable.
         This diminished power of contraction of the fibres of the muscles or organs of sense, which constitutes permanent debility or old age, may arise from a deficient secretion of sensorial power in the brain, as well as from the disobedience of the muscles and organs of sense to their usual stimuli; but this less production of sensorial power must depend on the inactivity of the glands, which compose the brain, and are believed to separate it perpetually from the blood; and is thence owing to a similar cause with the inaction of the fibres of the other parts of the system.
         It is finally easy to understand how the fibres may cease to act by the usual quantity of stimulus after having been previously exposed to a greater quantity of stimulus, or to one too long continued; because the expenditure of sensorial power has then been greater than its production; but it is not easy to explain why the repetition of fibrous contractions, which during the meridian of life did not expend the sensorial power faster than it was produced; or only in such a degree as was daily restored by rest and sleep, should at length in the advance of life expend too much of it; or otherwise, that less of it should be produced in the brain; or reside in the nerves; lastly that the fibres should become less excitable by the usual quantity of it.
         5. But these facts would seem to show, that all parts of the system are not changed as we advance in life, as some have supposed; as in that case it might have preserved for ever its excitability; and it might then perhaps have been easier for nature to have continued her animals and vegetables for ever in their mature state, than perpetually by a complicate apparatus to have produced new ones, and suffer the old ones to perish; for a further account of stimulus and the consequent animal exertion, see Zoonomia, Vol. I. Sect. 12.

II. Means of preventing old age.

         The means of preventing the approach of age must therefore consist in preventing the inexcitability of the fibres, or the diminution of the production of sensorial power.
         1. As animal motion cannot be performed without the fluid matter of heat, in which all things are immersed, and without a sufficient quantity of moisture to prevent rigidity: nothing seems so well adapted to both these purposes as the use of the warm bath; and especially in those, who become thin or emaciated with age, and who have a hard and dry skin, with hardness of the coat of the arteries; which feels under the finger like a cord; the patient should sit in warm water for half an hour every day, or alternate days, or twice a week; the heat should be about ninety-eight degrees on Fahrenheit's scale, or of such a warmth, as may be most agreeable to his sensation; but on leaving the bath he should always be kept so cool, whether he goes into bed, or continues up, as not sensibly to perspire.
         There is a popular prejudice, that the warm bath relaxes people, and that the cold bath braces them; which are mechanical terms belonging to drums and fiddle-strings, but not applicable except metaphorically to animal bodies, and then commonly mean weakness and strength: during the continuance in the bath the patient does not lose weight, unless he goes in after a full meal, but generally weighs heavier as the absorption is greater than the perspiration; but if he suffers himself to sweat on his leaving the bath, he will undoubtedly be weakened by the increased action of the system, and its exhaustion: the same occurs to those who are heated by exercise, or by wine, or spice, but not during their continuance in the warm bath: whence we may conclude, that the warm bath is the most harmless of all those stimuli, which are greater than our natural habits have accustomed us to; and that it particularly counteracts the approach of old age in emaciated people with dry skins.
         It may be here observed in favour of bathing, that some fish are believed to continue to a great age, and continually to enlarge in size, as they advance in life; and that long after their state of puberty. I have seen perch full of spawn, which were less than two inches long; and it is known, that they will grow to six or eight times that size; it is said, that the whales, which have been caught of late years, are much less in size than those, which were caught, when first the whale-fishery was established; as the large ones, which were supposed to have been some hundred years old, are believed to be already destroyed.
         All cold-blooded amphibious animals more slowly waste their sensorial power; as they are accustomed to less stimulus from their respiring less oxygen; and their movements in water are slower than those of aerial animals from the greater resistance of the element. There besides seems to be no obstacle to the growth of aquatic animals; as by means of the air-bladder, they can make their specific gravity the same as that of the water in which they swim. And the moisture of the element seems well adapted to counteract the rigidity of their fibres; and as their exertions in locomotion, and the pressure of some parts on others, are so much less than in the bodies of land animals.
         2. But as all excessive stimuli exhaust the sensorial power, and render the system less excitable for a time till the quantity of sensorial power is restored by sleep, or by the diminution or absence of stimulus; which is seen by the weakness of inebriates for a day at least after intoxication. And as the frequent repetition of this great and unnatural stimulus of fermented liquors produces a permanent debility, or disobedience of the system to the usual and natural kinds and quantities of stimulus, as occurs in those who have long been addicted to the ingurgitation of fermented liquors.
         And as, secondly, the too great deficiency of the quantity of natural stimuli, as of food, and warmth, or of fresh air, produces also diseases; as is often seen in the children of the poor in large towns, who become scrofulous from want of due nourishment, and from cold, damp, unairy lodgings.
         The great and principal means to prevent the approach of old age and death, must consist in the due management of the quantity of every kind of stimulus, but particularly of that from objects external to the moving organ; which may excite into action too great or too small a quantity of the sensorial power of irritation, which principally actuates the vital organs. Whence the use of much wine, or opium, or spice, or of much salt, by their unnatural stimulus induces consequent debility, and shortens life, on the one hand, by the exhaustion of sensorial power; so on the other hand, the want of heat, food, and fresh air, induces debility from defect of stimulus, and a consequent accumulation of sensorial power, and a general debility of the system. Whence arise the pains of cold and hunger, and those which are called nervous; and which are the cause of hysteric, epileptic, and perhaps of asthmatic paroxysms, and of the cold fits of fever.
         3. Though all excesses of increase and decrease of stimulus should be avoided, yet a certain variation of stimulus seems to prolong the excitability of the system; as during any diminution of the usual quantity of stimulus, an accumulation of sensorial power is produced; and in consequence the excitability, which was lessened by the action of habitual stimulus, becomes restored. Thus those, who are uniformly habituated to much artificial heat, as in warm parlours in the winter months, lose their irritability in some degree; and become feeble like hot-house plants; but by frequently going for a time into the cold air, the sensorial power of irritability is accumulated and they become stronger.
         Whence it may be deduced, that the variations of the cold and heat of this climate contribute to strengthen its inhabitants, who are more active and vigorous, and live longer, than those of either much warmer or much colder latitudes.
         This accumulation of sensorial power from diminution of stimulus any one may observe, who in severe weather may sit by the fire-side till he is chill and uneasy with the sensation of cold; but if he walks into the frosty air for a few minutes, an accumulation of sensorial power is produced by diminution of the stimulus of heat, and on his returning into the room where he was chill before, his whole skin will now glow with warmth.
         Hence it may be concluded, that the variations of the quantity of stimuli within certain limits contribute to our health; and that those houses which are kept too uniformly warm, are less wholesome than where the inhabitants are occasionally exposed to cold air in passing from one room to another.
         Nevertheless to those weak habits with pale skins and large pupils of the eyes, whose degree of irritability is less than health requires, as in scrofulous, hysterical, and sonic consumptive constitutions, a climate warmer than our own may be of service, as a greater stimulus of heat may be wanted to excite their less irritability. And also a more uniform quantity of heat may be serviceable to consumptive patients than is met with in this country, as the lungs cannot be clothed like the external skin, and are therefore subject to greater extremes of heat and cold in passing in winter from a warm room into the frosty air.
         4. It should nevertheless be observed, that there is one kind of stimulus, which though it be employed in quantity beyond its usual state, seems to increase the production of sensorial power beyond the, expenditure of it (unless its excess is great indeed) and thence to give permanent strength and energy to the system; I mean that of volition. This appears not only from the temporary strength of angry or insane people, but because insanity even cures some diseases of debility, as I have seen in dropsy, and in some fevers; but it is also observable, that many who have exerted much voluntary effort during their whole lives, have continued active to great age. This however may be conceived to arise from these great exertions being performed principally by the organs of sense, that is by exciting and comparing ideas; as in those who have invented sciences, or have governed nations, and which did not therefore exhaust the sensorial power of those organs which are necessary to life, but perhaps rather prevented them from being sooner impaired, their sensorial power not having been so frequently exhausted by great activity, for very violent exercise of the body, long continued, forwards old age; as is seen in post horses that are cruelly treated, and in many of the poor, who with difficulty support their families by incessant labour.

III. Theory of the Approach of Age.

         The critical reader is perhaps by this time become so far interested in this subject as to excuse a more prolix elucidation of it.
         In early life the repetition of animal actions occasions them to be performed with greater facility, whether those repetitions are produced by volition, sensation, or irritation; because they soon become associated together, if as much sensorial power is produced between every reiteration of action, as is expended by it.
         But if a stimulus be repeated at uniform intervals of time, the action, whether of our muscles or organs of sense, is performed with still greater facility and energy; because the sensorial power of association mentioned above, is combined with the sensorial power of irritation, and forms part of the diurnal chain of animal motions; that is, in common language, the acquired habit assists the power of the stimulus; see Zoonomia, Vol. I. Sect. XXII. 2. and Sect. XII. 3.
         On this circumstance depends the easy motions of the fingers in performing music, and of the feet and arms in dancing and fencing, and of the hands in the use of tools in mechanic arts, as well as all the vital motions which animate and nourish organic bodies.
         On the contrary, many animal motions by perpetual repetition are performed with less energy; as those who live near a waterfall, or a smith's forge, after a time, cease to hear them. And in those infectious diseases which are attended with fever, as the small-pox and measles, violent motions of the system are excited, which at length cease, and cannot again be produced by application of the same stimulating material; as when those are inoculated for the small-pox, who have before undergone that malady. Hence the repetition, which occasions animal actions for a time to be performed with greater energy, occasions them at length to become feeble, or to cease entirely.
         To explain this difficult problem we must more minutely consider the catenations of animal motions, as described in Zoonomia, Vol. I. Sect. XVII. The vital motions, as suppose of the heart and arterial system, commence from the irritation occasioned by the stimulus of the blood, and then have this irritation assisted by the power of association; at the same time an agreeable sensation is produced by the due actions of the fibres, as in the secretions of the glands, which constitutes the pleasure of existence; this agreeable sensation is intermixed between every link of this diurnal chain of actions, and contributes to produce it by what is termed animal causation. But there is also a degree of the power of volition excited in consequence of this vital pleasure, which is also intermixed between the links of the chain of fibrous actions; and thus also contributes to its uniform easy and perpetual production.
         The effects of surprise and novelty must now be considered by the patient reader, as they affect the catenations of action; and, I hope, the curiosity of the subject will excuse the prolixity of this account of it. When any violent stimulus breaks the passing current or catenation of our ideas, surprise is produced, which is accompanied with pain or pleasure, and consequent volition to examine the object of it, as explained in Zoonomia, Vol. I. Sect. XVIII. 17, and which never affects us in sleep. In our waking hours whenever an idea of imagination occurs, which is incongruous to our former experience, we feel another kind of surprise, and instantly dissever the train of imagination by the power of volition, and compare the incongruous idea with our previous knowledge of nature, and reject it by an act of reasoning, of which we are unconscious, termed in Zoonomia, "Intuitive Analogy," Vol. I. Sect. XVII. 7.
         The novelty of any idea may be considered as affecting us with another kind of surprise, or incongruity, as it differs from the usual train of our ideas, and forms a new link in this perpetual chain; which, as it thus differs from the ordinary course of nature, we instantly examine by the voluntary efforts of intuitive analogy; or by reasoning, which we attend to; and compare it with the usual appearances of nature.
         These ideas which affect us with surprise, or incongruity, or novelty, are attended with painful or pleasurable sensation; which we mentioned before as intermixing with all catenations of animal actions, and contributing to strengthen their perpetual and energetic production; and also exciting in some degree the power of volition, which also intermixes with the links of the chain of animal actions, and contributes to produce it.
         Now by frequent repetition the surprise, incongruity, or novelty ceases; and, in consequence, the pleasure or pain which accompanied it, and also the degree of volition which was excited by that sensation of pain or pleasure; and thus the sensorial power of sensation and of volition are subducted from the catenation of vital actions, and they are in consequence produced much weaker, and at length cease entirely. Whence we learn why contagious matters induce their effects on the circulation but once; and why, in process of time, the vital movements are performed with less energy, and at length cease; whence the debilities of age, and consequent death.